Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes
نویسندگان
چکیده
منابع مشابه
Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.
Interaction of the T cell receptor (TCR) with peptide/major histocompatibility complexes (MHC) in the thymus is of critical importance for developing thymocytes. In a previous study, we described an antagonist peptide that inhibited negative selection of transgenic thymocytes induced by an agonist peptide. In this study we show that this antagonist peptide can induce positive selection of CD8(+...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.14.8193